Polynucleotide, often referred to as PDRN (Polydeoxyribonucleotide), is a substance derived from salmon DNA. In aesthetic medicine, it has gained popularity for its regenerative properties. When applied to the skin, polynucleotide stimulates collagen production and enhances tissue repair. This natural component contributes to improved skin elasticity, hydration, and overall texture. As a non-surgical option, polynucleotide injections are recognised for promoting skin rejuvenation and addressing signs of aging. The treatment's bio-stimulating effects make it a valuable addition to skincare routines seeking to restore and revitalise the skin and eyes.